Lab Experiment

Research

GENETIC EPIDEMIOLOGY

Identification of genetic variants that confer susceptibility to hormonal cancers, particularly ovarian cancer, using next-generation sequencing and genotyping technologies. Click to learn more:

DNA

EPIGENOME OF OVARIAN CANCER

Although ovarian cancer has had little advancement for treatment, multiple histotypes have been identified and characterized with distinct epigenetics and genomics. OCRA establishes global maps of regulatory elements, defines histotype specific regulatory modules and identifies key regulators of these modules based on TF motif enrichments and regulator expression.

Image by National Cancer Institute

FUNCTIONAL GENOMICS

The key to risk assessment and prevention of a disease is to understand the basic biology of the disease. We can study these in an integrated fashion with genetic risk and mechanisms using 3C/4C technologies to identify physical interactions between risk variants and target genes. 

Using genes identified by 4C, we then develop CRISPR genome editing assays to validate variants associated with risk.

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Dot Pattern

SOMATIC VARIATION

Somatic are acquired mutations and the most common cause of cancer. These mutations occur from damage to genes in an individual cell during a person’s life. Somatic mutations are not found in every cell in the body and they are not passed from parent to child. 

Image by National Cancer Institute