EPIGENOME OF OVARIAN CANCER
Although ovarian cancer has had little advancement for treatment, multiple histotypes have been identified and characterized with distinct epigenetics and genomics. OCRA establishes global maps of regulatory elements, defines histotype specific regulatory modules and identifies key regulators of these modules based on TF motif enrichments and regulator expression.
The key to risk assessment and prevention of a disease is to understand the basic biology of the disease. We can study these in an integrated fashion with genetic risk and mechanisms using 3C/4C technologies to identify physical interactions between risk variants and target genes.
Using genes identified by 4C, we then develop CRISPR genome editing assays to validate variants associated with risk.
Learn more about our research by clicking Read More!