CAUSEL: AN EPIGENOME-AND GENOME-EDITING PIPELINE FOR ESTABLISHING FUNCTION OF NONCODING GWAS VARIANTS
Study of the non-coding regulatory regions of the genome is notoriously difficult, especially when it comes to identifying specific mechanism linking DNA variation to differences in regulatory activity and changes in the expression of one or more specific genes. Here we describe a procedure and steps for going about obtaining the necessary evidence in a principled and replicable fashion.
DNA METHYLATION LOSS IN LATE-REPLICATING DOMAINS IS LINKED TO MITOTIC CELL DIVISIONS
Loss of DNA methylation is one of the hallmarks of cellular aging and cancer progression. In this study, we showed how it is associated with late replication domains and therefore the breakdown of cell cycle regulation.
IDENTIFICATION OF 12 NEW SUSCEPTIBILITY LOCI FOR DIFFERENT HISTOTYPES OF EPITHELIAL OVARIAN CANCER
In this study, we used the new oncoarray genotyping platform to identify 12 novel risk loci associated with ovarian cancer. We performed a fine analysis of different histological subtypes of ovarian cancer. We also compared the locations of the risk associations on the genome with epigenomics features from relevant cell lines and tissues.