OCRA

Study of the non-coding regulatory regions of the genome is notoriously difficult, especially when it comes to identifying specific mechanism linking DNA variation to differences in regulatory activity and changes in the expression of one or more specific genes. Here we describe a procedure and steps for going about obtaining the necessary evidence in a principled and replicable fashion.

Loss of DNA methylation is one of the hallmarks of cellular aging and cancer progression. In this study, we showed how it is associated with late replication domains and therefore the breakdown of cell cycle regulation.

CRISPR is a new technology for genetic engineering of human (and many other) cells. This study created a resource for efficiently knocking out 1 or more genes in cell culture so their effects can be studied in a dish.

In this study, we used the new oncoarray genotyping platform to identify 12 novel risk loci associated with ovarian cancer. We performed a fine analysis of different histological subtypes of ovarian cancer. We also compared the locations of the risk associations on the genome with epigenomics features from relevant cell lines and tissues.