FUNCTIONAL COMPLEMENTATION STUDIES IDENTIFY CANDIDATE GENES AND COMMON GENETIC VARIANTS ASSOCIATED WITH OVARIAN CANCER SURVIVAL
The human genome contains 2 copies of every gene. A single copy of a cancer promoting gene may be sufficient for normal function, while loss of the second copy due to mutation processes (loss of heterozygosity or LOH) promotes cancer. This study used microarrays to identify associations of gene variants in 9 candidate genes with survival in ovarian cancer. We identified variations in two genes, Caspase 5 (CASP5) and retinoblastoma binding protein (RBBP8) that were associated with increased survival. We observed increased aggressiveness in 35% of the 314 ovarian cancer tumors with LOH in the RBBP8 gene.