A GENOME-WIDE ASSOCIATION STUDY IDENTIFIES A NEW OVARIAN CANCER SUSCEPTIBILITY LOCUS ON 9p22.2

A case/control study of ~4,000 people canvassing >500k common genetic variants identified a candidate list of a little over 22k variants potentially associated with ovarian cancer. A replication cohort of ~9,000 people from the US, Europe and Australia was then used to identify several high confidence variants in the region of chromosome 9 on the p arm (9p22.2). Varying risk with different subtypes of ovarian cancer were also reported.

Abstract

Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk. We performed a genome-wide association study (GWAS) to identify common ovarian cancer susceptibility alleles. We evaluated 507,094 SNPs genotyped in 1,817 cases and 2,353 controls from the UK and approximately 2 million imputed SNPs. We genotyped the 22,790 top ranked SNPs in 4,274 cases and 4,809 controls of European ancestry from Europe, USA and Australia. We identified 12 SNPs at 9p22 associated with disease risk (P < 10(-8)). The most significant SNP (rs3814113; P = 2.5 x 10(-17)) was genotyped in a further 2,670 ovarian cancer cases and 4,668 controls, confirming its association (combined data odds ratio (OR) = 0.82, 95% confidence interval (CI) 0.79-0.86, P(trend) = 5.1 x 10(-19)). The association differs by histological subtype, being strongest for serous ovarian cancers (OR 0.77, 95% CI 0.73-0.81, P(trend) = 4.1 x 10(-21)).

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