THE PAX8 CISTROME IN EPITHELIAL OVARIAN CANCER
The PAX8 transcription factor is a major driver of ovarian cancer. We show that knocking down PAX8 in ovarian cancer reduced its capacity to grow and divide. We used a technique called ChIP-seq to identify regions to which the PAX8 protein binds on the DNA genome. We performed the experiments in two widely used cell lines for ovarian cancer research, identified the genes most likely to be regulated by nearby PAX8 binding, and made comparisons between the two lines.